Jones G. Parker

Synaptic mechanisms modulate the spatiotemporal dynamics of striatal direct pathway neurons and motor output

This study shows that mGluR5 modulates co-activity of striatal direct pathway neurons and motor output through synaptic plasticity.

Parkinsonian striatal acetylcholine dynamics are refractory to L-DOPA treatment

This study investigates how L-DOPA treatment affects acetylcholine dynamics in the striatum under normal and parkinsonian conditions, finding that L-DOPA does not normalize these dynamics.

Top-down control of flight by a non-canonical cortico-amygdala pathway.

The paper identifies a non-canonical cortico-amygdala pathway from the dorsal peduncular prefrontal cortex to the central amygdala that regulates high-intensity defensive behaviors like flight.

Sucrose overconsumption impairs feeding circuit dynamics and promotes palatable food intake

This study shows that high-sucrose diets impair gut-brain communication by altering AgRP neuron activity, leading to increased palatable food intake.

Modulating D1 rather than D2 receptor-expressing spiny-projection neurons corresponds to optimal antipsychotic effect

The paper investigates the neural mechanisms of antipsychotic drugs by comparing their effects on D1- and D2-receptor-expressing spiny-projection neurons in mice, finding that modulating D1-SPNs correlates with therapeutic efficacy.

Selective Nigrostriatal Dopamine Excess Impairs Behaviors Linked to the Cognitive and Negative Symptoms of Psychosis

This study shows that selectively increasing dopamine in the dorsal striatum impairs behaviors linked to negative and cognitive symptoms of psychosis, challenging the idea that excess dopamine is not involved in these symptoms.

Striatal fiber photometry reflects primarily non-somatic activity

This study shows that striatal fiber photometry signals mainly reflect non-somatic calcium changes, not somatic ones.