Lisa R. Beutler

GIP receptor agonism suppresses inflammation-induced aversion and food intake via distinct circuits

This study shows that GIP receptor agonism reduces food intake and prevents aversion through distinct neural circuits, with different roles for CGRP neurons and the dorsal vagal complex.

IL-1β engages distinct peripheral sensory circuits to suppress feeding across time

This study identifies two distinct phases of IL-1β-induced anorexia mediated by different peripheral sensory circuits.

Incretin hormones and pharmacomimetics rapidly inhibit AgRP neuron activity to suppress appetite

This study shows that incretin hormone analogs inhibit AgRP neuron activity to suppress appetite, with GIP playing a unique role in nutrient-mediated inhibition.

Sucrose overconsumption impairs feeding circuit dynamics and promotes palatable food intake

This study shows that high-sucrose diets impair gut-brain communication by altering AgRP neuron activity, leading to increased palatable food intake.

Selective Nigrostriatal Dopamine Excess Impairs Behaviors Linked to the Cognitive and Negative Symptoms of Psychosis

This study shows that selectively increasing dopamine in the dorsal striatum impairs behaviors linked to negative and cognitive symptoms of psychosis, challenging the idea that excess dopamine is not involved in these symptoms.