Kamil K. Gebis

Single-cell transcriptional landscape of muscle-derived stem/progenitor cells reveals hallmarks of aging and rejuvenation

The paper profiles murine muscle-derived stem/progenitor cells across age groups using single-cell transcriptomics and proteomics, revealing a transcriptional continuum of maturation and aging-related changes.

IL-1β engages distinct peripheral sensory circuits to suppress feeding across time

This study identifies two distinct phases of IL-1β-induced anorexia mediated by different peripheral sensory circuits.

Ubiquitin Proteasome System Components, RAD23A and USP13, Modulate TDP-43 Solubility and Neuronal Toxicity

This study identifies RAD23A and USP13 as modifier genes that enhance TDP-43 solubility and reduce neuronal toxicity in ALS models.

Global Analysis of Aggregation Determinants in Small Protein Domains

The paper quantifies aggregation in small protein domains under stress and uses machine learning to identify predictors, improving aggregation prediction models.

Reduction of RAD23A extends lifespan and mitigates pathology in TDP-43 mice

This study shows that reducing RAD23A in TDP-43 mice improves survival, behavior, and reduces TDP-43 pathology and transcriptomic alterations.

Keratinocyte-derived exosomes in painful diabetic neuropathy

This study investigates keratinocyte-derived exosomes in a mouse model of painful diabetic neuropathy, finding differences in their molecular content and showing retrograde trafficking to DRG neurons.

Brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning

The paper develops DELTA, a method to measure brain-wide synaptic protein turnover at single-synapse resolution, revealing localized plasticity in hippocampal CA1 during learning.