Joshua Bugis

Activator-binding domains are required but insufficient for Med15 recruitment to UAS, revealing a critical role for its disordered C-terminus in directing genome targeting

The paper shows that Med15's activator-binding domains are necessary but not sufficient for UAS recruitment, and its disordered C-terminus is critical for directing genome targeting.

Beyond motif recognition: Specificity of human transcription factors in yeast

The paper investigates how human transcription factors bind specific DNA sites in yeast, finding that disordered regions influence binding selectivity beyond DNA motifs.