Vladimir Mindel

The paper shows that Med15's activator-binding domains are necessary but not sufficient for UAS recruitment, and its disordered C-terminus is critical for directing genome targeting.

The paper investigates how human transcription factors bind specific DNA sites in yeast, finding that disordered regions influence binding selectivity beyond DNA motifs.

The paper investigates how BMP and TGFβ pathways interact asymmetrically, showing that TGFβ inhibits BMP and BMP enhances TGFβ responses, reducing signaling ambiguity.

The paper analyzes the overlap between transcription factor binding and regulatory targets in yeast, finding that low overlap is due to weakly bound sites.

The paper introduces pMPBA, a method to analyze peptide-DNA binding in yeast, revealing determinants both within and outside predicted DNA binding domains.

The paper challenges the model of transcription factor binding cooperativity by showing limited effects of motif combinatorics in yeast using a novel massively parallel binding assay.