Beyond motif recognition: Specificity of human transcription factors in yeast
Joshua Bugis, Dan Reuben Zlotnik-Weinberg, Wajd Manadre, Vladimir Mindel, Yunwei Lu, Juan I. Fuxman Bass, Naama Barkai
The paper investigates how human transcription factors bind specific DNA sites in yeast, finding that disordered regions influence binding selectivity beyond DNA motifs.
bioRxiv · Apr 29, 2026 · PreprintGenetics