Un-LOK-ing a new approach for conformational selective targeting of STK10 (LOK)
Martina Dettenhöfer, Laura Nadine Tandara, Jennifer Alisa Amrhein, Christian Georg Kurz, Martin P. Schwalm, Theresa Elisabeth Mensing, L M Wahl, Andreas Krämer, Joshua Gerninghaus, Christopher Lenz, Lewis Elson, Benedict‐Tilman Berger, Martin Schröder, Krishna Saxena, Susanne Müller, , Thomas Hanke
The paper describes the optimization of a macrocyclic scaffold to develop a selective STK10 inhibitor with nanomolar activity and good kinome selectivity.
ACS Medicinal Chemistry Letters · Oct 14, 2025Peer-reviewedBiochemistry