Evaluation of peptidomimetic inhibitors
Christopher Lenz, Krishna Saxena, Stefan Knapp
The paper evaluates peptidomimetic inhibitors using a set of complementary assays to support drug discovery.
bioRxiv · Dec 15, 2025 · PreprintBiochemistry
Author
Krishna Saxena
Goethe University FrankfurtORCID 0000-0002-2237-5378Unclaimed ORCID profile · follow to get notified of new preprints
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2023-2025 · peak 3/yrCo-Author Collaboration Network
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Recent·Most cited
Overcoming Ligand Discovery Challenges: Developing Peptide-Based Tracers for SPSB2
Christopher Lenz, Lewis Elson, Johannes Dopfer, Frederic Farges, Andreas Krämer, Frank Löhr, Susanne Müller, Stéphanie M. Guéret, Herbert Waldmann, Volker Dötsch, Krishna Saxena, Stefan Knapp
This study develops peptide-based tracers for SPSB2 E3 ligase by conjugating cell-penetrating peptides to degrons, enabling efficient cellular delivery and target engagement assessment.
ACS Chemical Biology · Dec 8, 2025Peer-reviewedBiochemistry
Un-LOK-ing a new approach for conformational selective targeting of STK10 (LOK)
Martina Dettenhöfer, Laura Nadine Tandara, Jennifer Alisa Amrhein, Christian Georg Kurz, Martin P. Schwalm, Theresa Elisabeth Mensing, L M Wahl, Andreas Krämer, Joshua Gerninghaus, Christopher Lenz, Lewis Elson, Benedict‐Tilman Berger, Martin Schröder, Krishna Saxena, Susanne Müller, , Thomas Hanke
The paper describes the optimization of a macrocyclic scaffold to develop a selective STK10 inhibitor with nanomolar activity and good kinome selectivity.
ACS Medicinal Chemistry Letters · Oct 14, 2025Peer-reviewedBiochemistry
Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization
Martin P. Schwalm, Andreas Krämer, Anja Dölle, Janik Weckesser, Xufen Yu, Jian Jun Jin, Krishna Saxena, Stefan Knapp
This paper develops cell-based assays to monitor PROTAC degradation kinetics and ternary complex formation, revealing that ternary complex stability is critical for PROTAC efficiency.
Cell chemical biology · Jun 24, 2023Peer-reviewedMolecular Biology