Mengyan Zhang

Endogenous mutational mechanisms and metabolic context shape endometrial cancer

This study identifies subtype-specific mutational mechanisms and links them to host metabolic factors in endometrial cancer using genomic and transcriptomic data from 440 tumors.

A Thiopurine-like Mutagenic Process Defines TGCT Subtypes

This study identifies a unique mutational signature, SBS87, in testicular germ cell tumors (TGCTs) that resembles thiopurine-induced DNA damage and is associated with tumor latency and telomere elongation.

The dynamics of wild Vitis species in response to climate change facilitate the breeding of grapevine and its rootstocks with climate resilience

This study predicts future climate impacts on grapevine and wild Vitis species using ecological niche models, showing wild species may provide climate-resilient rootstocks for breeding.

Deep learning facilitates precise identification of disease-resistance genes in plants

This study introduces ESM-LRR and R-Predictor to identify disease-resistance genes in plants, achieving high accuracy in annotating R genes and predicting NLR-effector complexes.

Haplotype-resolved assemblies provide insights into genomic makeup of the oldest grapevine cultivar (Munage) in Xinjiang

This study presents haplotype-resolved genome assemblies for two Munage grapevine cultivars, identifies genes associated with fruit color traits, and highlights adaptive selection in ancient grapevines.