Radiotherapy drives lung metastasis in PDAC via a RhoGTPasesignaling shift towards MRCK-dependency
Kathy McLay, Mathias Tesson, Louise R. Dutton, Yihong Sun, Josette M Misquitta, Katrina H. Stevenson, Ryan Corbyn, Sérgio Lilla, Lynn McGarry, N Maka, R Shaw, Crispin J. Miller, LM Carlin, AJ Chalmers, Michael F. Olson, , JL Birch
This study shows that radiotherapy promotes lung metastasis in PDAC by increasing MRCK activity, which can be inhibited by BDP9066.
bioRxiv · Sep 9, 2025 · PreprintCancer Biology