Activity-dependent regulation of vascular cholesterol metabolism acts as a negative feedback mechanism for neurovascular coupling
Caterina P. Profaci, KL Foreman, Lena Spieth, Vanessa Coelho‐Santos, SA Berghoff, JT Fontaine, DA Jeffrey, Sean P. Palecek, EV Shusta, Gesine Saher, A. P. L. Shih, Fabrice Dabertrand, Richard Daneman
The paper shows neuronal activity increases brain endothelial cholesterol synthesis and uptake, which inhibits arteriole dilation and acts as a negative feedback mechanism for neurovascular coupling.
bioRxiv · Feb 23, 2024 · PreprintNeuroscience