Lena Spieth

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

This study investigates how TREM2 expression levels affect microglial function, metabolism, and response to TREM2 agonists in a mouse model of Alzheimer's disease.

Oligodendrocytes and neurons contribute to amyloid-β deposition in Alzheimer's disease

The paper shows oligodendrocytes contribute to amyloid-β plaques in Alzheimer's disease, but neurons are required for plaque formation.

Activity-dependent regulation of vascular cholesterol metabolism acts as a negative feedback mechanism for neurovascular coupling

The paper shows neuronal activity increases brain endothelial cholesterol synthesis and uptake, which inhibits arteriole dilation and acts as a negative feedback mechanism for neurovascular coupling.

Rescue of FTLD-associated TDP-43 pathology and neurodegeneration by peripheral AAV-mediated expression of brain-penetrant progranulin

Peripheral AAV-mediated delivery of brain-penetrant PGRN rescues TDP-43 pathology, neurodegeneration and motor phenotypes in FTLD-GRN models.

Ageing-associated myelin dysfunction drives amyloid deposition in mouse models of Alzheimer's disease

This study shows that ageing-related myelin dysfunction drives amyloid-beta deposition in Alzheimer's disease mouse models, suggesting myelin integrity as an upstream risk factor.

Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice

The paper shows that neuronal cholesterol synthesis is critical for remyelination in chronic demyelination models and MS patients.