Fabrice Dabertrand

This study identifies perivascular fibroblasts as regulators of cerebral vasomotion and cerebrospinal fluid movement through calcium dynamics and Gq signaling.

This study shows that purinergic receptor activation can correct endothelial dysfunction linked to autism in a mouse model by restoring bioenergetic function and cerebrovascular reactivity.

This study develops a mathematical model of cerebral mural cell electrophysiology and biomechanics to understand myogenic responses in arterioles and capillaries, revealing how Ca2+ dynamics and ion channel activity influence vascular resistance.

This study shows estrogen reduces myogenic tone in hippocampal arterioles by increasing nitric oxide release and endothelial SKCa channel activity in female mice.

VasoTracker 2 provides open-source software and low-cost hardware for analyzing vascular reactivity and function across multiple imaging modalities.

This paper develops micrometer-scale tPA beads that enhance plasmin generation and fibrinolysis, achieving rapid thrombus removal in a mouse stroke model with lower doses than standard tPA.

The paper investigates the role of microglia in maintaining blood-brain barrier properties in health and finds that microglia are not required, but PLX5622 treatment affects endothelial cholesterol metabolism.

The paper shows neuronal activity increases brain endothelial cholesterol synthesis and uptake, which inhibits arteriole dilation and acts as a negative feedback mechanism for neurovascular coupling.