Gesine Saher

The paper shows that retinal ganglion cell activity induces correlated astrocyte calcium waves in the superior colliculus, dependent on mGluR5 and mGluR3, suggesting a conserved mechanism across sensory systems.

The paper shows oligodendrocytes contribute to amyloid-β plaques in Alzheimer's disease, but neurons are required for plaque formation.

The paper shows neuronal activity increases brain endothelial cholesterol synthesis and uptake, which inhibits arteriole dilation and acts as a negative feedback mechanism for neurovascular coupling.

The paper challenges the view that axonal degeneration in MS results from immune-mediated damage by proposing that myelin itself increases axonal degeneration risk under inflammatory conditions.

This study shows that ageing-related myelin dysfunction drives amyloid-beta deposition in Alzheimer's disease mouse models, suggesting myelin integrity as an upstream risk factor.

The paper shows ketamine suppresses futility-induced passivity in zebrafish by modulating astroglial calcium through norepinephrine signaling.

This study shows that a hypercaloric diet causes temporary molecular changes in astrocytes specifically in the arcuate nucleus of the hypothalamus.

The paper shows that neuronal cholesterol synthesis is critical for remyelination in chronic demyelination models and MS patients.

The paper identifies Kir4.1 and Connexin43 as Nedd4-2 substrates, showing their regulation impacts astrocytic function and neuronal network activity.