Non-canonical caspase-8 activation by cathepsin B drives anti-inflammatory human macrophage polarization
Emeline Kerreneur, Paul Chaintreuil, Chloe Delaby, Sonia Boulakirba, Maxence Bourgoin, Morgane Fajolles, Cécile Favreau, Adèle Rivault, Juba Bennour, Nathalie M Droin, Jean‐François Peyron, Johanna Chiche, Thomas Cluzeau, Michael L. Loschi, Patrick Auberger, , Arnaud Jacquel
This study identifies cathepsin B as a novel upstream activator of non-apoptotic caspase-8, driving anti-inflammatory macrophage polarization and differentiation.
bioRxiv · Aug 22, 2025 · PreprintImmunology