Thomas Cluzeau

Dual targeting of GPX4 and TXNRD1 triggers eradication of AML cells through induction of apoptosis and ferroptosis

The paper identifies two compounds that target GPX4 and TXNRD1 to induce apoptosis and ferroptosis in AML cells, effectively eradicating malignant cells while sparing normal hematopoietic cells.

Non-canonical caspase-8 activation by cathepsin B drives anti-inflammatory human macrophage polarization

This study identifies cathepsin B as a novel upstream activator of non-apoptotic caspase-8, driving anti-inflammatory macrophage polarization and differentiation.

Genome-wide association study identifies susceptibility loci for acute myeloid leukemia

This study identifies two genome-wide significant susceptibility loci for acute myeloid leukemia through a meta-analysis of GWAS data.