Nathalie M Droin

Glycometabolic, inflammatory and exocrine plasma proteins predict cancer in individuals with cardiovascular disease

The paper identifies a plasma protein signature that predicts cancer in patients with cardiovascular disease, using data from two cohorts.

Transient reprogramming limits AP-1-associated chromatin opening and transposable element activation to preserve hematopoietic stem cell function during aging and stress

This study shows that transient reprogramming with Yamanaka factors delays and partially reverses HSC aging and stress-induced decline by limiting AP-1 chromatin opening and transposable element activation.

Single-cell multiplex approaches deeply map ON-target CRISPR-genotoxicity and reveal its mitigation by palbociclib and long-term engraftment

The paper develops a multiplexed single-cell approach to monitor CRISPR-induced genotoxicity and shows that palbociclib reduces genomic rearrangements in hematopoietic cells.

AXL mediates mast cell survival and resistance to tyrosine kinase inhibitors in mastocytosis

This study identifies AXL as a driver of mast cell survival and TKI resistance in mastocytosis and shows that dual KIT/AXL inhibition restores TKI sensitivity.

Non-canonical caspase-8 activation by cathepsin B drives anti-inflammatory human macrophage polarization

This study identifies cathepsin B as a novel upstream activator of non-apoptotic caspase-8, driving anti-inflammatory macrophage polarization and differentiation.

NOX4 prevents the recruitment of PAX8 and NKX2.1 to chromatin in BRAF-mutated thyroid cancer cells.

The paper shows that NOX4-generated ROS repress NIS in BRAFV600E-mutated thyroid cancer cells by blocking PAX8 and NKX2.1 chromatin binding through DNA damage and epigenetic mechanisms.

CXCL8 secreted by immature granulocytes inhibits wildtype hematopoiesis in chronic myelomonocytic leukemia

The paper identifies CXCL8 secreted by immature granulocytes as a factor inhibiting wildtype hematopoiesis in CMML, suggesting CXCL8 blockade could slow disease progression.

DiPRO1 dependent transcriptional and epigenetic regulation distinctly controls the fate of muscle and mesenchymal cancer cells.

This paper identifies DiPRO1 as a regulator of myoblast differentiation and mesenchymal tumor suppression through epigenetic and transcriptional mechanisms, showing its potential as a therapeutic target.

Targeting Heterochromatin Eliminates Malignant Stem Cells in Chronic Myelomonocytic Leukemia Through Reactivation of Retroelements and Innate Immune pathways

This study shows that combining DNA hypomethylating agents with H3K9me2 inhibitors reactivates immune pathways and eliminates malignant stem cells in CMML by targeting heterochromatin disorganization.