Dual targeting of GPX4 and TXNRD1 triggers eradication of AML cells through induction of apoptosis and ferroptosis
Cécile Favreau, Maxence Bourgoin, Coline Savy, Thomas Botton, Sarah Bailly, Florence Granger, Catherine Birck, Marwa Zerhouni, Emeline Kerreneur, Adèle Rivault, Alban Vigroux, Jade Dussart‐Gautheret, Marie-Laure Arcangeli, Arnaud Poterszman, Thomas Cluzeau, , Guillaume Robert
The paper identifies two compounds that target GPX4 and TXNRD1 to induce apoptosis and ferroptosis in AML cells, effectively eradicating malignant cells while sparing normal hematopoietic cells.
Experimental Hematology and Oncology · Mar 31, 2026Peer-reviewedBiochemistry