Arterial Elastin Abundance, Rather Than Orthologue Origin, Modulates Medial Arterial Calcification in Matrix Gla Protein-Deficient Mice
Juliana Marulanda, Ophélie Gourgas, Abhinav Parashar, Robert P. Mecham, Elaine C. Davis, Marta Cerruti, Juergen Brinckmann, Monzur Murshed
The paper shows that arterial elastin abundance, not its origin, affects medial calcification in MGP-deficient mice, with reduced elastin delaying calcification and human elastin restoring it.
bioRxiv · Sep 1, 2026 · PreprintCell Biology