TAF2 condensation in nuclear speckles links basal transcription factor TFIID to RNA splicing
Tanja Bhuiyan, Niccolò Arecco, Paulina Karen Mendoza Sanchez, Juhyeong Kim, Carsten Schwan, Sophie Weyrauch, Sheikh Nizamuddin, Andrea Prunotto, Mehmet Tekman, Martin Lothar Biniossek, Bettina Liebowitz Knapp, Stefanie Koidl, Friedel Drepper, Pitter F. Huesgen, Robert Grosse, , Sebastian J. Arnold
This study shows TAF2's intrinsically disordered region drives condensation in nuclear speckles, recruiting SRRM2 to TFIID and affecting alternative splicing.
Cell Reports · Apr 25, 2025Peer-reviewedMolecular Biology