Mehmet Tekman

Familial medullary thyroid carcinoma secondary to an SLC30A9 intragenic deletion and translation reinitiation

The paper identifies an SLC30A9 deletion causing familial medullary thyroid carcinoma through translation reinitiation and shows its oncogenic effects.

Competing regulatory modules control the transition between mammalian gastrulation modes

The paper identifies two regulatory modules that control the sequential transition between early and late gastrulation modes in mouse gastruloids.

TAF2 condensation in nuclear speckles links basal transcription factor TFIID to RNA splicing

This study shows TAF2's intrinsically disordered region drives condensation in nuclear speckles, recruiting SRRM2 to TFIID and affecting alternative splicing.

Eomes restricts Brachyury functions at the onset of mammalian gastrulation

The paper investigates the distinct gene-regulatory functions of Eomes and Brachyury in mouse embryos and stem cells, showing Eomes restricts Brachyury activity to ensure proper lineage specification.

An EOMES induced epigenetic deflection initiates lineage commitment at mammalian gastrulation

The paper identifies EOMES-induced chromatin accessibility as a key step in initiating mesendoderm lineage commitment during mammalian gastrulation.

A Single-cell RNA-seq Training and Analysis Suite using the Galaxy Framework

The paper introduces a Galaxy-based suite for scRNA-seq analysis, offering workflows, training resources, and tools for preprocessing, normalization, and clustering across 10x and alternative platforms.