Pitter F. Huesgen

Modular assembly of mitochondrial complex III from a dynamic matrix domain pool

This study reveals how mitochondrial complex III assembles from preformed matrix domain modules, showing dynamic subunit exchange and the role of specific residues in assembly and disease.

Distinct core minor pilin complexes prime specialized type IV filaments in cyanobacteria

This study identifies two distinct core minor pilin complexes in cyanobacteria that prime specialized Type IV filaments for natural competence and motility.

An ER Retrieval-and-Release System Reveals Ligand-Independent Basal Signaling by Cell Surface TCRs

The paper develops an ER retrieval-and-release system to study ligand-independent basal TCR signaling, finding that surface TCRs generate distinct phosphorylation patterns compared to ligand-induced activation.

Arabidopsis cysteine protease RD19 limits RBOHD-generated ROS production in pattern triggered immunity

This study shows RD19 limits RBOHD-generated ROS in PTI by regulating its accumulation, and identifies AED3 and AED2/ASPG1 as potential RD19 substrates.

Powering methanogenesis from fatty acids by a twin-heme-mediated reverse redox-loop

This paper reports cryo-EM structures of EMO and EMO-ETF complex from Syntrophus aciditrophicus, revealing a twin-heme-mediated reverse redox-loop mechanism for methanogenesis from fatty acids.

Deletion of the gene for a cyanobacterial ribosome-associated protein affects the carbon/nitrogen metabolism

This paper characterizes the function of the cyanobacterial gene ssr3189 by analyzing its deletion mutant, revealing its role in linking translation with metabolic control and RNA decay.

Regulation of Sulfolobus acidocaldarius surface structures by the PP2A core interaction module

This study identifies a PP2A regulatory network in Sulfolobus acidocaldarius that controls surface structures and motility through phosphorylation-dependent signaling.

Processing and release of the maize phytocytokine Zip1

This study identifies a two-stage proteolytic pathway for maize phytocytokine Zip1 maturation and release, revealing spatial and temporal control of immune signaling.

The TARGET OF RAPAMYCIN (TOR) kinase controls shade-mediated hypocotyl elongation responses in Arabidopsis

This study identifies the TOR complex 1 as a key regulator of shade-mediated hypocotyl elongation in Arabidopsis, showing its role in auxin-dependent growth responses and epidermal cell elongation.

Systems-level Plant Responses Reveal Pseudomonas-Mediated Growth Promotion in Brachypodium Under Nitrogen Limitation

The paper investigates how Brachypodium interacts with Pseudomonas koreeensis under nitrogen limitation, showing increased biomass and nitrogen content in inoculated plants.

The compartmentalized activity of a legume subtilase SBT12a allows symbiosome stabilization

This study identifies SBT12a as a subtilase that regulates symbiosome stability in legumes by degrading defense proteins and promoting symbiosis.

Rejuvenation of the Aged Cerebrovascular System via Protein Corona-Guided Fusogenic Liposome Delivery

This paper develops ApoE-functionalized fusogenic liposomes to deliver resveratrol to the brain, improving vascular function and cognitive performance in aged mice with reduced drug dosage.

Functional Characterization of Target of Rapamycin (TOR) Signalling in Physcomitrella

This study investigates TOR signalling in Physcomitrella, showing it positively controls growth, development, chloroplast function, protein synthesis, and cell cycle progression.

Structural organization of p62 filaments and the cellular ultrastructure of calcium-rich p62-enwrapped lipid droplet cargo

This study determines the cryo-EM structure of p62 and visualizes its filament organization and calcium-rich lipid droplet cargo in cells under stalled autophagy.

Proteomic characterization of sporadic clear cell renal cell carcinoma reveals a matrix-dense pseudocapsule and heterogeneous tumor subtypes

This study uses proteomics to characterize sporadic ccRCC, identifying a matrix-dense pseudocapsule and five tumor subtypes with distinct biological features.

ERAD machinery controls the conditional turnover of PIN-LIKES in plants

This study shows that ERAD machinery regulates PILS protein turnover in plants under non-stressed conditions, linking ER protein homeostasis to growth regulation.

Filamentous growth, cell envelope architecture, and surface appendages of a member of the Chloroflexota, Litorilinea aerophila

This study examines the growth, morphology, and surface appendages of Litorilinea aerophila, revealing unique features of its cell envelope and multicellular organization.

TAF2 condensation in nuclear speckles links basal transcription factor TFIID to RNA splicing

This study shows TAF2's intrinsically disordered region drives condensation in nuclear speckles, recruiting SRRM2 to TFIID and affecting alternative splicing.

Involvement of RNase J in CRISPR RNA maturation in the cyanobacterium Synechocystis sp. PCC 6803

This study identifies RNase J as a new enzyme involved in crRNA maturation in the type III-Bv CRISPR-Cas system of Synechocystis sp. PCC 6803, working with RNase E and possibly another RNase.

Ribosome-inactivation by a class of widely distributed C-tail anchored membrane proteins

The paper identifies YqjD/ElaB/YgaM as ribosome-hibernating proteins that inhibit translation by blocking the ribosomal tunnel, similar to antimicrobial peptides and macrolide antibiotics.

Structural plasticity of bacterial ESCRT-III protein PspA in higher-orderassemblies

The paper determines cryo-EM structures of PspA rods and shows how structural plasticity is mediated by conformational changes and protomer contacts.

Bioengineering secreted proteases converts divergent Rcr3 orthologs and paralogs into extracellular immune co-receptors

This study bioengineers proteases to convert Rcr3 orthologs and Pip1 into immune co-receptors that trigger Avr2/Cf-2 dependent immunity in tomato.

Barley powdery mildew invasion coincides with the dynamic accumulation of leaf apoplastic extracellular vesicles that are associated with host stress response proteins

This study investigates the dynamics of extracellular vesicles in barley leaves during powdery mildew infection, finding increased abundance and specific protein associations with infection progression.

Design of a Biohybrid Materials Circuit with Binary Decoder Functionality

The paper designs a biohybrid materials circuit with binary decoder functionality using protease-based modules to detect small molecules and produce regulated protease outputs.