Sebastian J. Arnold

This study identifies PRMT1 as a critical regulator of trophoblast development, showing its role in preventing early pregnancy loss through epigenetic control of stemness and differentiation.

This study examines how hypomorphic IFT and dynein-2 mutations affect chondrogenic differentiation, ECM composition, and Wnt signaling in ATDC5 organoids, revealing genotype-dependent changes in signaling pathways and ECM.

This study shows that migrating mouse primordial germ cells face increasing physical confinement and DNA damage during their journey to the gonads.

This study performs time-resolved transcriptomic and ECM proteomic analyses of differentiating ATDC5 cells to characterize chondrogenesis and cartilage ECM formation.

The paper identifies two regulatory modules that control the sequential transition between early and late gastrulation modes in mouse gastruloids.

This study shows TAF2's intrinsically disordered region drives condensation in nuclear speckles, recruiting SRRM2 to TFIID and affecting alternative splicing.

This study shows that Nodal and Wnt signalling act antagonistically during mammalian gastrulation, with Nodal promoting anterior structures and Wnt driving posterior development.

Cyclin O is necessary for multiciliated cells to enter their differentiation cell cycle variant and allows the massive amplification of centrioles, which serve as basal bodies for cilia nucleation.

The paper investigates the distinct gene-regulatory functions of Eomes and Brachyury in mouse embryos and stem cells, showing Eomes restricts Brachyury activity to ensure proper lineage specification.

The paper identifies EOMES-induced chromatin accessibility as a key step in initiating mesendoderm lineage commitment during mammalian gastrulation.

This paper introduces chimeric 3D-gastruloids as a tool to study mammalian peri-gastrulation development by combining genetically distinct cells to investigate gene function and phenotypes.

The paper investigates the spatiotemporal sequence of mesoderm and endoderm lineage segregation during mouse gastrulation using genetic fate labeling, imaging, and scRNA-seq.

This study shows that Eomes and Brachyury control pluripotency exit and germ layer segregation by altering chromatin states, with Tbx factors repressing pluripotency and NE gene programs while enabling ME differentiation.

The paper quantifies progenitor cell outputs in the developing mouse neocortex, showing stochastic lineage generation of pyramidal cells leading to diverse laminar configurations.