Mislocalisation of TDP-43 to the cytoplasm of either neurons or oligodendrocytes causes axonopathy and dysmyelination
Marcus Keatinge, Sandra Constantinou Juhasz, Toby Shaw-McGrath, Julia Albayrak, Daniel Y. H. Soong, Katy LH Marshall-Phelps, David Story, Laura J. Hoodless, James D. Cooper, Rafael Almeida, Tim Czopka, Giles E. Hardingham, David Anthony Lyons, Siddharthan Chandran
This study shows that mislocalisation of TDP-43 to the cytoplasm in neurons or oligodendrocytes causes axonopathy and dysmyelination, highlighting the role of cell-type-specific loss of function in neurodegeneration.
bioRxiv · Nov 17, 2025 · PreprintNeuroscience