Rafael Almeida

This study uses live-imaging of endogenous neurofascins in zebrafish to show glial neurofascin shapes developing nodes of Ranvier.

This study shows that oligodendrocytes internalize exogenous myelin, enhancing their proliferation and differentiation through transcriptional changes and lipid droplet formation.

This study shows that mislocalisation of TDP-43 to the cytoplasm in neurons or oligodendrocytes causes axonopathy and dysmyelination, highlighting the role of cell-type-specific loss of function in neurodegeneration.

AQuA2 quantifies molecular spatiotemporal signals from live imaging data by decomposing complex datasets into signaling events, demonstrating applications across biosensors and cell types.

This study identifies a retroviral origin of vertebrate myelin by showing that RNLTR12-int retrotransposon regulates myelination through SOX10 interaction in multiple vertebrates.

This study identifies VAMP2/3-mediated exocytosis as essential for CNS myelin membrane expansion, revealing a pathway critical for myelin formation and potential therapeutic targeting.

The paper shows that clusters of Neurofascin A on axons predict node of Ranvier positions before myelination, independent of myelin sheath growth.

This study shows that disrupting NKCC1 in Schwann cells impairs their response to neuronal activity, leading to myelin defects and nerve pathology, which can be reversed by TTX treatment.