Marcus Keatinge

This study shows that mislocalisation of TDP-43 to the cytoplasm in neurons or oligodendrocytes causes axonopathy and dysmyelination, highlighting the role of cell-type-specific loss of function in neurodegeneration.

This study shows that C9ORF72 deficiency in zebrafish causes retinal degeneration, including reduced thickness, gliosis, and neuronal loss, but not spinal cord pathology.

The paper uses synthetic CRISPR gRNAs and in vivo pre-screening to identify pro-regenerative genes in spinal cord injury, finding that tgfb1a promotes regeneration by controlling inflammation.

The paper investigates the additive effect of genetic risk variants for Parkinson's disease and finds an unexpected rescue effect on neuronal function and survival in zebrafish with combined GCase and ASM deficiency.

The paper shows that macrophage-mediated dynamic control of Il-1β and Tnf-α is essential for spinal cord regeneration in zebrafish.