Giles E. Hardingham

Mononuclear myeloid cells mount an adaptive protective response to intracerebral haemorrhage by activation of NRF2

The paper identifies NRF2 activation in mononuclear myeloid cells as a protective response to intracerebral haemorrhage, showing its therapeutic potential through modulation of interferon pathways.

Astrocytes transform the transcriptomic and epigenetic landscape of developing cortical neurons to promote activity via intrinsic excitability control

This study shows astrocytes alter the transcriptomic and epigenetic landscape of developing cortical neurons, promoting intrinsic excitability and influencing disease-related pathways.

Mislocalisation of TDP-43 to the cytoplasm of either neurons or oligodendrocytes causes axonopathy and dysmyelination

This study shows that mislocalisation of TDP-43 to the cytoplasm in neurons or oligodendrocytes causes axonopathy and dysmyelination, highlighting the role of cell-type-specific loss of function in neurodegeneration.

FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation

This study shows FAK regulates glycolysis and glutamine oxidation in glioblastoma stem cells, affecting mitochondrial morphology and cell migration.

Absence of short-term axon initial segment plasticity in human, mouse, and rat cortical circuits

The paper tests for axon initial segment (AIS) structural plasticity in human, mouse, and rat cortical neurons across different conditions and finds no evidence of AIS length changes over short-term activity modulation.

Astrocytes control motor neuronal mitochondrial axonal transport deficits in C9ORF72 ALS.

This study shows that C9ORF72-mutant astrocytes disrupt axonal transport in motor neurons, and correcting this rescues transport deficits.

Altered GluN2A levels reduce the emergence of seizure-like events in a rat model of GRIN2A haploinsufficiency

This study shows that reduced GluN2A expression in rat models decreases seizure-like activity in specific in vitro epilepsy models.

Wild type bone marrow-derived microglia-like cells mitigate strain-dependent neuropathology in Csf1r mutant mice.

The paper shows that wild-type bone marrow-derived microglia-like cells reduce strain-dependent neuropathology in Csf1r mutant mice by preventing thalamic calcification.

Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus

This study shows that neurodevelopmental processes in the cortex and thalamus can occur normally without microglia, using a genetically modified mouse model.

Microglia determine beta-amyloid plaque burden but are non-essential for downstream pathology

This study shows microglia promote beta-amyloid plaque formation but are not required for subsequent pathological changes in Alzheimer's disease.

Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer's disease via MFG-E8

The paper shows human astrocytes and microglia ingest more synapses in Alzheimer's disease via MFG-E8, and inhibiting MFG-E8 reduces this ingestion in cultured cells.

Astrocyte-Oligodendrocyte interaction regulates central nervous system regeneration

The paper shows that astrocyte-oligodendrocyte interaction is critical for remyelination and identifies a drug strategy targeting this interaction to promote central nervous system regeneration.

Evolutionary divergence of basal and activity-dependent exon splicing in cortical neurons

The paper compares human and mouse exon usage in cortical neurons, finding conservation in basal inclusion but divergence in activity-dependent usage, suggesting both cis-acting and trans-acting factors contribute to species differences.

LAB-AID (Laboratory Automated Interrogation of Data): an interactive web application for visualization of multi-level data from biological experiments

LAB-AID is an interactive web tool that visualizes and interrogates hierarchical biological experimental data to improve understanding and identify outliers and batch effects.

Altered dendritic spine function and integration in a mouse model of Fragile X Syndrome

This study shows that loss of FMRP in a mouse model of Fragile X Syndrome leads to increased single-spine excitation and more multiply-innervated spines, contributing to circuit hyperexcitability.

Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte-myelin dysfunction

The paper investigates the impact of a t(1;11) translocation on white matter integrity and oligodendrocyte-myelin function using DTI and cellular models.

Reducing tau ameliorates behavioural and transcriptional deficits in a novel model of Alzheimer’s disease

This study shows that reducing tau improves behavioural and transcriptional issues in a mouse model of Alzheimer’s disease, suggesting synaptic tau reduction could be a therapeutic strategy.