Dissociation of SYNGAP1 Enzymatic and Structural Roles: Intrinsic Excitability and Seizure Susceptibility
Julia Brill, Blaise Alexander Clarke, Ingie Hong, Richard L. Huganir
This study shows that SYNGAP1's structural role, not its enzymatic GAP activity, is critical for seizure susceptibility in heterozygous KO mice, while its GAP activity affects intrinsic excitability.
Proceedings of the National Academy of Sciences · Apr 28, 2025Peer-reviewedNeuroscience