Ingie Hong

Optimizing the efficiency of assisted reproduction procedures in the common marmoset (Callithrix jacchus) improved IVF outcomes

This study optimizes IVF procedures in common marmosets by identifying factors like progesterone levels and stimulation duration that improve embryo development and implantation rates.

Analysis of sperm processing and cryopreservation procedures in the common marmoset (Callithrix jacchus) to reduce fragmentation and maximize total and progressive motility

The paper optimizes sperm processing and cryopreservation methods in common marmosets to improve motility and reduce DNA fragmentation for IVF applications.

Reactive Astrocytes Drive Extracellular Acidification to Mediate α-Synuclein Neurodegeneration

This study identifies a mechanism by which reactive astrocytes drive neurodegeneration in synucleinopathies through extracellular acidification and neuronal ASIC1a activation.

Syngap1 and the development of murine neocortical progenitor cells

This study shows that Syngap1 absence or haploinsufficiency does not affect murine neocortical progenitor properties or output, suggesting species-specific or methodological differences in SYNGAP1's role in neurogenesis.

CRISPR-mediated transcriptional activation as a mutation-independent therapeutic strategy for SYNGAP1-related intellectual disability

This paper demonstrates that CRISPR-mediated transcriptional activation can upregulate SYNGAP1 in a mouse model of SRID and human neurons, rescuing deficits without targeting mutations.

Dissociation of SYNGAP1 Enzymatic and Structural Roles: Intrinsic Excitability and Seizure Susceptibility

This study shows that SYNGAP1's structural role, not its enzymatic GAP activity, is critical for seizure susceptibility in heterozygous KO mice, while its GAP activity affects intrinsic excitability.

Calcium-permeable AMPA receptors govern PV neuron feature selectivity

This study shows that calcium-permeable AMPA receptors (CP-AMPARs) in PV interneurons reduce their feature selectivity, and removing them increases selectivity in visual cortex and hippocampus.

Mouse models of SYNGAP1-related intellectual disability

This paper generates two knock-in mouse models with human SYNGAP1 mutations causing intellectual disability, showing reduced protein levels and recapitulating key disease features.

SynGAP regulates synaptic plasticity and cognition independent of its catalytic activity

This study shows SynGAP regulates synaptic plasticity and cognition through phase separation, not its catalytic activity.

Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors

The paper develops tools to track synaptic plasticity in vivo by imaging endogenous AMPA receptors and generates a detailed spatiotemporal map of synaptic changes during behavior.

All-or-none disconnection of pyramidal inputs onto parvalbumin-positive interneurons gates ocular dominance plasticity

The paper shows that monocular deprivation in mouse visual cortex causes an all-or-none elimination of pyramidal cell connections to parvalbumin-positive interneurons, which is necessary for ocular dominance plasticity.

SynGAP splice isoforms differentially regulate synaptic plasticity and dendritic development

This study shows that different SynGAP splice variants have distinct roles in synaptic plasticity and dendritic development through unique spatiotemporal expression and phase separation properties.