Cellular protein delivery through membrane potential driven water pores
Jonathan Franke, Palina Dubatouka, Amin Yourdkhani, Sahil Soni, Tillmann Utesch, Juliana Serrano, Tolga Soykan, Martin Lehmann, Han Sun, Jan Vincent V. Arafiles, Christian P. R. Hackenberger
This study reveals how CPP-additives enable direct membrane translocation of proteins by inducing transient water pores, offering insights for optimizing protein delivery strategies.
bioRxiv · Feb 25, 2026 · PreprintBiochemistry