Jan Vincent V. Arafiles

Cellular protein delivery through membrane potential driven water pores

This study reveals how CPP-additives enable direct membrane translocation of proteins by inducing transient water pores, offering insights for optimizing protein delivery strategies.

An engineered nanobody inhibitor for molecular-to-circuit control of opioid receptor function

This paper develops an engineered nanobody inhibitor to control opioid receptor function with subcellular precision and demonstrates its effectiveness in vivo.

Active Site-Directed Probes for targeting Bacterial Phosphoarginine Phosphatases

This paper introduces covalent activity-based probes to study phosphoarginine phosphatases, identifying new enzymes and expanding understanding of bacterial signal transduction.