Christian P. R. Hackenberger

This paper develops a cell-permeable nanobody to restore function of the misfolded F508del-CFTR protein in CF bronchial epithelial cells.

This study reveals how CPP-additives enable direct membrane translocation of proteins by inducing transient water pores, offering insights for optimizing protein delivery strategies.

This paper develops an engineered nanobody inhibitor to control opioid receptor function with subcellular precision and demonstrates its effectiveness in vivo.

This paper introduces covalent activity-based probes to study phosphoarginine phosphatases, identifying new enzymes and expanding understanding of bacterial signal transduction.

The paper uses mass photometry to analyze how small-molecule inhibitors disrupt GNE oligomerization, finding concentration-dependent destabilization and competitive binding.

TUB-010 is an anti-CD30 ADC using Tub-tag conjugation technology that reduces toxicity and improves therapeutic window compared to Adcetris.

This study identifies oligophosphorylation as a new phosphorylation mode, showing NME1 can catalyze its own oligophosphorylation using ATP, with implications for phosphoregulation.

This study identifies glycoRNA as a novel component of the alveolar epithelial glycocalyx and shows its role in barrier regulation and viral infection.