Dysfunctional β-cell longevity in diabetes relies on high energy conservation and positive epistasis
Kavit Raval, Neema Jamshidi, Berfin Seyran, Łukasz Salwiński, Raju K. Pillai, Lixin Yang, Feiyang Ma, Matteo A. Pellegrini, Juliana Shin, Xia Yang, Slavica Tudzarova
The paper identifies PFKFB3-expressing dysfunctional β-cells in T2D, showing their survival via positive epistasis and reduced clearance, and demonstrates PFKFB3 inhibition restores glucose tolerance in mice.
Life Science Alliance · Sep 23, 2024Peer-reviewedCell Biology