Activity-dependent development of the body's touch receptors
Celine Santiago, Julianna Siegrist, Nusrat Africawala, Annie Handler, Aniqa Tasnim, Rabia Anjum, Josef Turecek, Brendan P. Lehnert, Sophia Renauld, Jinheon Choi, Michael Nolan-Tamariz, Michael Iskols, Alexandra R. Magee, Suzanne Paradis, Nikhil Sharma, David D. Ginty
This study shows that neuronal activity is essential for the development of touch receptors, as genetic disruption of Piezo2 and Nav1.6 leads to structural and functional defects in mechanosensory neurons.
Neuron · May 16, 2025Peer-reviewedNeuroscience