Michael Iskols

Intravital pH Imaging using the sensor ApHID Reveals Incomplete Lysosomal Acidification in Resident Meningeal Phagocytes.

The paper uses ApHID-dextran to measure lysosomal pH in mouse meningeal phagocytes, revealing incomplete acidification and changes under pathological conditions.

Activity-dependent development of the body's touch receptors

This study shows that neuronal activity is essential for the development of touch receptors, as genetic disruption of Piezo2 and Nav1.6 leads to structural and functional defects in mechanosensory neurons.

An axon - T cell feedback loop enhances inflammation and axon degeneration

The paper shows that a feedback loop between axons and T cells exacerbates inflammation and axon degeneration in mouse skin.

Three-dimensional reconstructions of mechanosensory end organs suggest a unifying mechanism underlying dynamic, light touch

This study uses 3D reconstructions of mechanosensory end organs to propose a unified mechanism for Aβ RA-LTMR activation through axon protrusions and Piezo2 distribution.

Krause corpuscles of the genitalia are vibrotactile sensors required for normal sexual behavior

This study identifies Krause corpuscles as vibrotactile sensors in the genitalia essential for normal sexual behavior in mice.

A DRG genetic toolkit reveals molecular, morphological, and functional diversity of somatosensory neuron subtypes

The paper develops a genetic toolkit to study DRG neuron subtypes, revealing their molecular, morphological, and functional diversity in response to mechanical and thermal stimuli.