A tumor-suppressive role of the PRC1 Polycomb epigenetic complex in the maintenance of adult Drosophila intestinal stem cell identity
Aurélia Joly, Ana-Maria Popmihaylova, Corinne Rancurel, Julie Soltys, Rihab Loudhaief, Armel Gallet, Edan Foley (27365), Anne‐Marie Martinez, Raphaël Rousset
This paper shows that PRC1 suppresses tumor formation in Drosophila intestinal stem cells by maintaining their identity, and identifies immune pathways that limit tumor growth.
PLoS Genetics · Jul 17, 2026Peer-reviewedCancer Biology