The chloride cotransporter NKCC1 regulates self-renewal of hippocampal neural stem cells via the transcription factor Sox11
Antonia Blank, Sneha Adhikarla, Julius Broesske, Lucas Kaiser, Magdalene Rippe, Madlen Haase, Marco Groth, Gregor Stein, Tina Andrä, Jessica Mesterheide, Anna-Lena Fleischer, Tom Floßmann, Iris Schäffner, Elisabeth Sock, Knut Kirmse, , Silke Keiner
This study shows that NKCC1 regulates hippocampal neural stem cell self-renewal via Sox11, with reduced NKCC1 in aging promoting symmetric division and decreased neurogenesis.
bioRxiv · Jul 1, 2025 · PreprintNeuroscience