This study shows that SOX4/11 transcription factors are critical for mitotic fidelity in adult hippocampal precursor cells, with loss leading to mitotic defects and cell death.

bioRxiv · Oct 13, 2025 · PreprintCell Biology

The chloride cotransporter NKCC1 regulates self-renewal of hippocampal neural stem cells via the transcription factor Sox11

Antonia Blank, Sneha Adhikarla, Julius Broesske, Lucas Kaiser, Magdalene Rippe, Madlen Haase, Marco Groth, Gregor Stein, Tina Andrä, Jessica Mesterheide, Anna-Lena Fleischer, Tom Floßmann, Iris Schäffner, Elisabeth Sock, Knut Kirmse, , Silke Keiner

This study shows that NKCC1 regulates hippocampal neural stem cell self-renewal via Sox11, with reduced NKCC1 in aging promoting symmetric division and decreased neurogenesis.

bioRxiv · Jul 1, 2025 · PreprintNeuroscience

Enhanced mitochondrial fusion during a critical period of synaptic plasticity in adult-born neurons

Sandra M.V. Kochan, Meret Cepero Malo, Milica Jevtic, Hannah M. Jahn-Kelleter, Gulzar A. Wani, Kristiano Ndoci, Laura Pérez-Revuelta, Felix Gaedke, Iris Schäffner, Dieter Chichung Lie, Astrid C Schauss, Matteo Bergami

The paper shows that mitochondrial fusion during a critical period supports synaptic plasticity and circuit integration in adult-born neurons.

Neuron · Apr 5, 2024Peer-reviewedNeuroscience