Madlen Haase

Expression trajectories in the aging male mouse colon transcriptome

This study identifies nonlinear gene-expression trajectories in the aging male mouse colon, revealing midlife transitions and a transcriptomic clock based on three genes.

Social isolation of aged mice drives dramatic release of inflammatory lipoxygenase-derived oxylipins

This study shows social isolation in aged mice increases inflammatory oxylipins in multiple organs but not serum, with exercise failing to reduce these effects.

NKCC1 a Regulator of Glioblastoma Progression

This study investigates NKCC1's role in glioblastoma progression, finding it correlates with recurrence-free survival and is expressed in stem-like and astrocytic cells.

Multi-omics analysis highlights the link of aging-related cognitive decline with systemic inflammation and alterations of tissue-maintenance

The paper integrates multi-omics data from mice to identify molecular features linked to aging-related cognitive decline, highlighting systemic inflammation and microbiome-driven gut-brain axis dysfunction.

The chloride cotransporter NKCC1 regulates self-renewal of hippocampal neural stem cells via the transcription factor Sox11

This study shows that NKCC1 regulates hippocampal neural stem cell self-renewal via Sox11, with reduced NKCC1 in aging promoting symmetric division and decreased neurogenesis.

Metabolic modeling reveals the aging-associated decline of host-microbiome metabolic interactions in mice

This study uses multi-omics and metabolic modeling in mice to show that aging reduces host-microbiome metabolic interactions, affecting key host pathways involved in intestinal barrier function and homeostasis.