Self-reporting transposons enable simultaneous readout of gene expression and transcription factor binding in single cells
Arnav Moudgil, Michael Wilkinson, Xuhua Chen, June He, Alexander J. Cammack, Michael J. Vasek, Tomás Lagunas, Zongtai Qi, Matthew A. Lalli, Chuner Guo, Samantha A. Morris, Joseph D. Dougherty, Robi David Mitra
This paper introduces self-reporting transposons (SRTs) and the scCC assay to simultaneously capture gene expression and TF binding in single cells, demonstrating their use in cultured cells and mouse cortex.
Cell · Jul 24, 2020Peer-reviewedGenomics