Michael J. Vasek

This study evaluates the role of AQP4 readthrough isoforms in gliovascular functions using a novel mouse model and finds that AQP4x modulates BBB integrity and protein localization.

The paper shows that microglia perform local protein synthesis in peripheral processes to support phagocytic activity and lysosomal machinery assembly.

This paper introduces self-reporting transposons (SRTs) and the scCC assay to simultaneously capture gene expression and TF binding in single cells, demonstrating their use in cultured cells and mouse cortex.

The paper uses CRISPR TRAPseq to show QKI is important for astrocytic maturation and synaptic control in vivo.

The paper introduces FLEX Calling Cards, a method to map transcription factor-DNA interactions in specific cell types within heterogeneous tissues using viral delivery and transposon insertion.

The paper shows astrocytes perform local translation in their peripheral processes, identifies candidate transcripts, and links them to synaptic regulation.