Pyruvate kinase allostery resist hyperglycemia, obesity and inflammation by inducing TCA vortex and glucose U turn
Xuan Zhang, Xudong Jiang, Xiaobin Wu, Youhao Yang, Jintian Wang, Junfeng Zheng, Miao Zhou, Qian Chen
This study shows that CLT-PKM interaction mimics ATP resistance by inducing a TCA vortex and glucose U turn, leading to weight loss and antioxidant effects against hyperglycemia, obesity, and inflammation.
bioRxiv · Aug 9, 2024 · PreprintBiochemistry