Xuan Zhang

Pyruvate kinase allostery resist hyperglycemia, obesity and inflammation by inducing TCA vortex and glucose U turn

This study shows that CLT-PKM interaction mimics ATP resistance by inducing a TCA vortex and glucose U turn, leading to weight loss and antioxidant effects against hyperglycemia, obesity, and inflammation.

Systematic Evaluation of Different R-loop Mapping Methods: Achieving Consensus, Resolving Discrepancies and Uncovering Distinct Types of RNA:DNA Hybrids

The paper evaluates eight R-loop mapping technologies, identifies biases and artifacts, and classifies R-loops into two distinct types based on RPA binding patterns.

Therapeutic Reversal of Chemically Induced Parkinson Disease by Converting Astrocytes into Nigral Neurons

This study converts astrocytes into functional neurons to reverse Parkinson's disease in mice by suppressing PTB, restoring dopamine levels and nigrostriatal pathways.