Gut delivery of pentameric GLP-1 using genetically engineered Bacillus subtilis
Ningyuan Ye, Francesco Di Pierro, Nicola Zerbinati, Alexander Bertuccioli, Chaorui Duan, Jingchen Xu, Ivan Paul Thaddeus Anterola, Collins Chimezie, Jure Zupet, Jiahe Li
This paper develops an engineered Bacillus subtilis spore system for sustained gastrointestinal delivery of pentameric GLP-1, showing glucose-lowering and weight-reduction effects in mice.
ACS Synthetic Biology · Oct 27, 2026Peer-reviewedBioengineering