Author

Ningyuan Ye

University of Michigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Microbiology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:metagenomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Jiahe LiiD· 3 shared Maria Jennings· 2 shared Noah T. HutchinsoniD· 2 shared Alexander BertuccioliiD· 1 shared Chaorui DuaniD· 1 shared Chengyuan FangiD· 1 shared Collins Chimezie· 1 shared Francesco Di PierroiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBioengineering

Jiahe LiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Gut delivery of pentameric GLP-1 using genetically engineered Bacillus subtilis

Ningyuan Ye, Francesco Di Pierro, Nicola Zerbinati, Alexander Bertuccioli, Chaorui Duan, Jingchen Xu, Ivan Paul Thaddeus Anterola, Collins Chimezie, Jure Zupet, Jiahe Li

This paper develops an engineered Bacillus subtilis spore system for sustained gastrointestinal delivery of pentameric GLP-1, showing glucose-lowering and weight-reduction effects in mice.

ACS Synthetic Biology · Oct 27, 2026Peer-reviewedBioengineering

Engineered Lactate Catabolizing Probiotics Reveal Timescale Dependent Microbiome-Host Metabolic Coupling

Noah T. Hutchinson, Ningyuan Ye, Maria Jennings, Chengyuan Fang, Nathan Qi, Jiahe Li

This paper shows that engineered probiotics converting lactate to pyruvate acutely alter microbiota and host metabolism but fail to improve chronic obesity, highlighting homeostatic limits of gut-targeted therapies.

bioRxiv · Apr 8, 2026 · PreprintMicrobiology

Engineered Bacillus subtilis as oral probiotics to enhance clearance of blood lactate

Mengdi Yang, Noah T. Hutchinson, Ningyuan Ye, Hania Timek, Maria Jennings, Jianing Yin, Ming Guan, Zongqi Wang, Peiru Chen, Shaobo Yang, Justin D. Crane, Ke Zhang, Xuesong He, Jiahe Li

This paper engineers Bacillus subtilis spores to deliver lactate oxidase to the gut, reducing blood lactate in mice without disrupting microbiota or organ function.

ACS Synthetic Biology · Dec 31, 2024Peer-reviewedSynthetic Biology