Jiahe Li

Gut delivery of pentameric GLP-1 using genetically engineered Bacillus subtilis

This paper develops an engineered Bacillus subtilis spore system for sustained gastrointestinal delivery of pentameric GLP-1, showing glucose-lowering and weight-reduction effects in mice.

Tumor-tropic E. coli engineered as living T and NK cell engagers

This paper develops LIME, a bacterial platform that engagers T and NK cells to target tumors, showing enhanced cytotoxicity and immune response in preclinical models.

Modeling Microbiome Modulation of Tumor Metabolic Networks to Predict Synergistic Therapies

This paper develops a framework combining machine learning and metabolic modeling to predict synergistic cancer therapies influenced by microbiome composition in colorectal cancer.

Engineering tumor-homing bacteria as membrane-anchored immune checkpoint-blockade interfaces

This paper engineers tumor-homing bacteria to display immune checkpoint-blocking nanobodies, showing enhanced tumor suppression in mouse models compared to traditional antibody therapies.

Engineered Lactate Catabolizing Probiotics Reveal Timescale Dependent Microbiome-Host Metabolic Coupling

This paper shows that engineered probiotics converting lactate to pyruvate acutely alter microbiota and host metabolism but fail to improve chronic obesity, highlighting homeostatic limits of gut-targeted therapies.

Programmable conjugative CRISPR interference targeting genotoxin in the gut

This paper develops a CRISPRi system to suppress colibactin production in pks E. coli, reducing DNA damage and tumorigenesis in mice.

Physiologically Relevant Coculture Model for Oral Microbial-Host Interactions

This paper introduces a coculture model that simulates oral oxygen gradients to study microbial-host interactions and antibiotic efficacy.

Engineered Bacillus subtilis as oral probiotics to enhance clearance of blood lactate

This paper engineers Bacillus subtilis spores to deliver lactate oxidase to the gut, reducing blood lactate in mice without disrupting microbiota or organ function.

Identification of P-type ATPase as a bacterial transporter for host-derived small RNA

This study identifies a bacterial P-type ATPase transporter, PtaT, that specifically binds and mediates the uptake of host-derived tsRNAs in Fusobacterium nucleatum.