Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease
Kejia Zhang, Patrick Eldin, Jessica H. Ciesla, Laurence Briant, Jenna M. Lentini, Jillian Ramos, Justin Cobb, Joshua C. Munger, Dragony Fu
This study shows that SARS-CoV-2 main protease Nsp5 cleaves and inactivates TRMT1, a host tRNA modification enzyme, leading to reduced tRNA modifications and viral RNA levels in infected cells.
eLife · May 30, 2024Peer-reviewedMolecular Biology