Jillian Ramos

The study shows that Z domain mutations in ADAR1p150 slightly reduce A-to-I editing, likely due to mislocalization rather than editing specificity loss, and suggests phenotypes may stem from ZBP1 inhibition.

This study shows that SARS-CoV-2 main protease Nsp5 cleaves and inactivates TRMT1, a host tRNA modification enzyme, leading to reduced tRNA modifications and viral RNA levels in infected cells.

This study shows that a mutation in ADAT3, linked to intellectual disability, disrupts tRNA wobble inosine formation and ADAT2/ADAT3 complex function.

This paper introduces a method using gamma-toxin endonuclease to detect mcm5s2U modification in eukaryotic tRNAs and shows its conservation across species.