Jessica H. Ciesla

This study identifies EGLN1 as essential for HCMV infection by mediating mitochondrial activation to increase dNTP pools required for viral DNA replication.

The paper introduces a CRISPR screening method called VIRCAA to identify genes affecting HCMV infection, finding JUNB as an anti-viral factor.

This study shows that SARS-CoV-2 main protease Nsp5 cleaves and inactivates TRMT1, a host tRNA modification enzyme, leading to reduced tRNA modifications and viral RNA levels in infected cells.

This study identifies the UL26-PIAS1 complex as a mechanism by which HCMV inhibits anti-viral gene expression and promotes cell-to-cell spread.