Author

Laurence Briant

Centre National de la Recherche ScientifiqueORCID 0000-0002-1995-3501Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Éric BernardiD· 2 shared Patrick EldiniD· 2 shared Angéline Tellier· 1 shared Anne‐Laure Favier· 1 shared Annemarie Fortuin· 1 shared Arnaud Lecante· 1 shared Aude Boulay· 1 shared Aymeric NeyretiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersMicrobiology

Éric BernardORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Zika virus reprograms the host tRNA epitranscriptome to adapt translation to A-ending codon bias

Patrick Eldin, Éric Bernard, Cathrine Broberg Vågbø, Sara Salinas, Lynn George, Masahiko Ajiro, Masatoshi Hagiwara, Geir Slupphaug, Laurence Briant

This study shows Zika virus reprograms host tRNA modifications to favor AA-ending codons, enhancing viral protein translation and replication.

bioRxiv · Jun 3, 2025 · PreprintMicrobiology

The human plasma amino acids balance favours HIV replication in primary CD4 T lymphocytes

Lise Chauveau, Annemarie Fortuin, Arnaud Lecante, Nina Lager-Lachaud, Angéline Tellier, Shravya Honne, Aude Boulay, Fabien P. Blanchet, Baek Kim, Floriant Bellvert, Laurence Briant, Jean‐Luc Battini

The study shows that amino acid balance, not energy metabolism, promotes HIV-1 replication in primary CD4 T cells under near-physiological conditions.

bioRxiv · Dec 10, 2024 · PreprintMicrobiology

Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease

Kejia Zhang, Patrick Eldin, Jessica H. Ciesla, Laurence Briant, Jenna M. Lentini, Jillian Ramos, Justin Cobb, Joshua C. Munger, Dragony Fu

This study shows that SARS-CoV-2 main protease Nsp5 cleaves and inactivates TRMT1, a host tRNA modification enzyme, leading to reduced tRNA modifications and viral RNA levels in infected cells.

eLife · May 30, 2024Peer-reviewedMolecular Biology

In situ characterization of late Chikungunya virus replication organelle

Justine Girard, Olivier Le-Bihan, Joséphine Lai‐Kee‐Him, Maria Gîrleanu, Éric Bernard, Cédric Castellarin, Aymeric Neyret, Danièle Spehner, Xavier Holy, Anne‐Laure Favier, Laurence Briant, Patrick Bron

This study uses cryogenic-electron microscopy to characterize late-stage Chikungunya virus replication organelles in human cells, revealing their structural heterogeneity and dynamic roles in viral replication and protein production.

bioRxiv · Feb 25, 2023 · PreprintMolecular Biology